Dynamics of Rhythm Generation



  • The ability of distinct circuits to generate patterns of rhythmic activity is widespread among vertebrate and invertebrate species. These patterns correspond to different functions like control of different rhythmic movements and pathological events like seizure episodes. The dynamics of the circuits producing such patterns are based on the basic principles conserved across phyla. This workshop will investigate roles of interactions of processes on different time and space scales in attaining the robustness and flexibility, characteristic for living circuits. For example, we will discuss the roles played by Na+/K+ pump and ion exchangers in generation of functional and dysfunctional rhythms.
  • We would like to bring together experts applying experimental approaches and the methods developed in the neuroscience, neurophysics, neuro-informatics, neuroethology, and the bifurcation theory to determine the basic principles of the transient, intermittent, and steady dynamics of rhythm generation from different phyla.

    • Organizer: Gennady Cymbalyuk

    For questions contact Gennady Cymbalyuk (gcymbalyuk@gsu.edu).

    Registration: Attendance to all CNS workshops is subject to registration at the conference website.

    The workshop will be held at UW Medicine Brotman Auditorium

    Schedule

    Invited Speakers:

    8:50 - 9:00
    		Gennady Cymbalyuk
    Opening Remarks
    9:00 - 9:45
    		Ilya Rybak (Drexel University, Philadelphia, USA)
    "Respiratory CPG: Insights from optogenetic and modeling studies"
    9:45 -10:30
    		Yaroslav Molkov (GSU, Atlanta, USA)
    "TRP channels and intracellular calcium dynamics in the pre-Bötzinger complex"
    10:30 - 11:00
    		Coffee break
    11:00 - 11:45
    		Nino Ramirez (Seattle Children's Hospital, Seattle, USA)
    "Dynamic mechanisms underlying respiratory rhythm generation"
    11:45 - 12:30
    		Astrid Prinz (Emory University, Atlanta, USA)
    "Mechanisms for stabilizing rhythm generation"
    12:30 - 14:00
    		Lunch break
    14:00 - 14:45
    		Irene Elices (Universidad Autónoma de Madrid, Madrid, Spain)
    "Dynamical invariants: cycle-by-cycle rhythm negotiation"
    14:45 - 15:30
    		Anatoly Buchin (Allen Institute for Brain Science, Seattle, USA)
    "Epileptic seizures as pathological oscillations in neural network and neural mass models"
    15:30 - 16:00
    		Coffee break
    16:00 - 16:45
    		Yina Wei (Allen Institute for Brain Science, Seattle, USA)
    "Differentials roles of sleep spindles and sleep slow oscillations in memory consolidation"
    16:45 - 17:30
    		Gennady Cymbalyuk (GSU, Atlanta, USA)
    "Roles of the Na+/K+ pump current in generation of bursting patterns"